Formulation and Development of Mucoadhesive Curcumin Tablet

Abstract

The main objective of this study was to improve the bioavailability of curcumin through oral route
administration for gastric wound healing property. Curcumin mucoadhesive tablet were prepared
using ethyl cellulose as a matrix and carbopol, HPMC K15M, HPC, CMC, chitosan and Gum Karaya
as a mucoadhesive polymer by an Wet Granualtion technique.Valuable delivery of the drugs for the
gastric wound healing management , for local action and treatment of gastric disorders such as
gastric cancer, gastric ulcers can be achieved by Mucoadhesive dosage forms like single and multiple
unit systems belong to the Gastroretentive Drug Delivery System.Curcumin is practically insoluble in
water. Thats why mucoadhesive drug delivery system was prepared along with different
concentration of mucoadhesive polymer. Therefore an attempt has been made to improve the
bioavailability by using different conc. of mucoadhesive polymer as the mechanism of bioadhesion.
Curcumin tablets were prepared by Wet granulation compression with different ratio of HPMC.K4M.
(1, 2.5, 5, and 7.5%) as bioadhesive polymer and Hydroxy propy cellulose (10, 20, 30 and 40%) as
layer. The formulation were characterized for physicochemical parameter such as weight variation,
thickness, hardness, friability, mucoadhesive strength, drug content, swelling studies and in vitro
diffusion studies. The best mucoadhesive performance and in vitro drug release profile were exhibited
by tablets containing hydroxy propyl methyl cellulose K4M (5%) and different containing polymer
with different ratios (%). This product was more comfortable to the user due to absence of erosion,
faster hydration rate and less viscosity of surrounding environment. To conclude that the formulated
unidirectional, single layered, muccoadhesive tablet for curcumin using HPMC and carbopol as
mucoadhesive agent is superior to oral conventional tablets, as it has the potential effect and improve
the bioavailability of curcumin..