A Review Paper on Natural Products in Drug Innovation Procedure

Abstract

As a source of medicinal agents, natural products and their associated moieties have traditionally been unbelievable. Research into natural products in the pharmaceutical industry has declined over the last 5-10 years due to issues such as the lack of consistency with high-throughput screening of conventional natural-product extract libraries. Natural-product structures have long been recognized to have the characteristics of high chemical diversity, biochemical specificity and other molecular properties that make them favorable to drug discovery as lead structures, and that help to distinguish them from synthetic and combinatorial compound libraries. Over the past decades, recent developments in genomics and structural biology have painted a better image of the variety of proteins targeted by the molecules of natural products. Besides these, emerging methods for lead generation have contributed to a renewed interest in drug development in natural products. This paper provides a detailed review on the procedure of the natural products in the drug innovation.