A REVIEW PAPER ON COATING NANOPARTICLES FOR DRUG DELIVERY
Targeted delivery makes it possible to absorb drug molecules preferentially at the sites of action and thus holds great promise to enhance the therapeutic index. Nanoparticle-based delivery systems, among different drug-targeting methods, give some specific strengths and have achieved exciting preclinical and clinical outcomes. This is a summary of the recent development of the cell membrane-coated nanoparticle method, a new class of biomimetic nanoparticles that incorporates both cell membrane functionality and the engineering versatility of synthetic nano materials for efficient drug delivery and innovative therapeutics. This review focuses in particular on novel cell membrane-coated nanoparticles designs, as well as their underlying principles that promote drug targeting purposes. Three particular areas are highlighted, including: I coating of the cell membrane to prolong nanoparticle circulation, (ii) coating of the cell membrane to achieve cell-specific targeting, and (iii) coating of the cell membrane for targeting the immune system. Overall, nanoparticles coated with cell membrane have emerged as a new class of targeted nano therapeutics with high potential for enhancing drug delivery and therapeutic efficacy for the treatment of different diseases.