A REVIEW ON THE APPLICATION OF HYDROGEL BASED SENSORS FOR BIOMEDICAL

Abstract

In recent years, biosensors that identify and transform biochemical processes to a detectable signals have gained a lot of interest. More than 150,000 papers covering the application of biosensors in multiple industries were reported around 1950 and 2017, but important reports describing hydrogel-based biosensors for biomedical applications are uncommon to the best of our understanding and without diligent screening. The biomedical application of hydrogel-based biosensors is addressed in this study, based on a search conducted over the years 2000-2017 through the Network of Science Core, PubMed (NLM) and Science Direct online databases. We considered bioreceptors to be immobilised on hydrogel-based biosensors, their benefits and drawbacks, and strategies of immobilisation in this study. Along with the prevailing transduction strategies, we characterise the hydrogels that are most preferred for this form of biosensor. Biomedical applications of hydrogel-based biosensors are explained, involving cell metabolite and pathogen identification, tissue engineering, wound healing, and cancer tracking, and techniques are established for the identification of tiny biomolecules such as glucose, lactate, urea, and cholesterol.