Fabrication And Evaluations Of Extended Release Matrix Tablets Of Aceclofenac (BCS CLASS II DRUG): In Vitro Buoyancy Studies

  • Vishnu Kant, Dr. Gajendra Singh Rathore

Abstract

The oral route is considered as the most promising route of drug delivery. Effective oral drug delivery
may depend upon the factors such as gastric emptying process, gastrointestinal transit time of dosage
form, drug release from the dosage form and site of absorption of drugs. Aceclofenac is an orally
administered phenyl acetic acid derivatives with effects on a variety of inflammatory mediators.
Through its analgesic and anti-inflammatory properties, Aceclofenac provides symptomatic relief in a
variety of painful conditions. The purpose of present work to prepare gastro retentive floating tablets
of Aceclofenac to sustained the drug release as well as prolong the presence of the dosage form in the
stomach until all the drug is completely released in the desired period of time to prolong, gastric
residence time and increase its bioavailability. Rapid gastrointestinal transit could result in
incomplete drug release from the drug delivery system above the absorption zone leading to
diminished efficacy of the administered dose. The present work was undertaken with the aim to
formulate and evaluate the gastro retentive floating tablets of Aceclofenac. The effervescent-based
floating drug delivery was a promising approach to achieve in vitro buoyancy. The addition of gelforming polymer and gas-generating agent sodium bicarbonate was essential to achieve in vitro
buoyancy. The type of polymer affects the drug release rate and the mechanism. From results
obtained, it was concluded that the formulation of gastro retentive tablet of Aceclofenac containing a
combination of polymers (HPMC K-100M, HPMC K-15 and Guar gum ) was taken as ideal
formulation for released the drug in a controlled manner for extended period of time by maintaining
the buoyancy.

Published
2019-12-31
Section
Articles