FORMULATION, OPTIMIZATION AND EVALUATION OF NANOCRYSTAL FORMULATION FOR POORLY SOLUBLE DRUG

Abstract

A model drug 3-hydroxy-3-methylglutaryl-coenzyme (HMG-CoA) selected for study which is known for lipid lowering activity is characterized by poor water solubility and bioavailability. In present study precipitated nanocrystals formulated by using  by anti-solvent technique i,e bottom up technique are formulated for drug selected for study. Stabilizers with varying concentration were used and optimized for providing sheath around nancocrystals.  Precipitated nanocrystals so obtained were further evaluated, by determining their size, zeta potential (ZP), saturated solubility and in-vitro dissolution studies. Results revealed that Formulation F-9 having drug polymer ratio i,e 1:3(Drug: stabilizer) demonstrated the highest saturated solubility, dissolution rate, and particle size of 592.1 nm  and hence was analysed by  thermal method for analysis eg. X-ray diffraction analysis, differential scanning calorimetry, Fourrier transform infrared spectroscopy for any interaction between drug and excipients used and scanning electron microscopy was performed to detect any morphological changes. Increase in saturation solubility was attributed to increase in surface area.