Synthesis, spectral Characterization and Antimicrobial Activity of 2-(furan-2-yl)-5-hydroxy-4H-chromen-4-one

Abstract

Flavonoids are also known as plant pigments or co-pigments. Flavonoids are the largest group of naturally occurring phenolic compounds which occur in different plant parts both in a free state and as glycosides. 2-(furan-2-yl)-5-hydroxy-4H-chromen-4-one was synthesized by Claisen-Schmidt condensation method from 2,6-dihydroxy acetophenone  and 2-furaldehyde to gives chalcone and which on oxidation with DMSO/I2.Spectroscopic characterization using UV-visible, IR, ¹H NMR, Mass spectra, properties and antimicrobial activity has been investigated for 2-(furan-2-yl)-5-hydroxy-4H-chromen-4-one. The IR bands for Carbonyl group (-C=O in pyron ring) for 2-(furan-2-yl)-5-hydroxy-4H-chromen-4-one appear at 1605 per cm which agrees with the general range of flavones. The 2-(furan-2-yl)-5-hydroxy-4H-chromen-4-one has two matching bands at 245 nm and other at 360 nm which lies in the range of flavone. In the mass spectrum of 2-(furan-2-yl)-5-hydroxy-4H-chromen-4-one molecular ion peak is observed m/z and calculated m/z corresponding to [M⁺]  peaks is in good agreement with their structure. The flavone shows moderate to good Antibacterial and Antifungal activity.